New Frontiers in Uveitis Management: Five Drugs to Watch
The management of uveitis is rapidly evolving with the introduction of novel therapeutic molecules targeting key inflammatory pathways. This article highlights five promising drugs currently under clinical evaluation, offering hope for more effective and safer treatment options. While early results are encouraging, most of these agents are yet to complete phase 3 trials, and their long-term safety...Read More
Ten Pearls in the Management of Uveitis
While the diagnosis and treatment of uveitis may seem like a daunting task to the beginner, there are some tips and tricks which help to identify specific uveitides and help in appropriate treatment. If it looks like a duck, swims like a duck and quacks like a duck, chances are, it is probably a duck. 1. Infectious vs Non infectious : It is crucial to make this differentiation as , even though cer...Read More
Intraocular Lymphoma: Ten Points Every Ophthalmologist Should Know
1. Epidemiology of Intraocular Lymphoma: Intraocular Lymphoma is a rare malignancy accounting for 0.01% of ophthalmic conditions. The term includes primary intraocular lymphoma (PIOL) with or without primary central nervous system lymphoma (PCNSL). 1 Majority of the patients with lymphoma are over 50 years of age. 2 2. Presentations and Potential for Misdiagnosis of Intraocular Lymphoma: PIOL has ...Read More
Ten Tenets Every Ophthalmologist should know about Collaborative Ocular TB Study (COTS)
“Ocular tuberculosis, a disease that we fear, Stealthily attacks the eyes, year after year. In the dark and quiet, it spreads its deadly grime, Causing pain and inflammation, and a loss of sight sometimes. Choroidal TB is the commonest sight, With serpiginous-like choroiditis, it takes its flight. Retinal vasculitis too, causes so much pain, Ocular tuberculosis, an insidious foe, it will remain. B...Read More
HLA-B27 associated Acute Anterior Uveitis
Introduction Acute anterior uveitis (AAU) results from a breakdown of the blood-aqueous barrier and acute inflammation of the iris and ciliary body. It is the most common form of uveitis encountered the world over. Keratic precipitates (KPs) are characteristic of AAU and represent inflammatory cells that deposit on the corneal endothelium due to the upregulation of adhesion molecules in response t...Read More
Introduction: Toxoplasmosis is the most common cause of posterior uveitis in the world, accounting for over 80% of the cases in some regions[1-5]. For many years, ocular toxoplasmosis was considered to be the result of the recurrence of the congenital form of the disease [6]. However, it is recently believed that acquired infections might be a more important cause of ocular diseases than congenita...Read More
Human immunodeficiency virus (HIV) disease is a pandemic of global concern, not only due to serious health issues affecting all organs of the body but also due to its huge economic burden.(1) The diagnosis is often associated with social stigma that includes changing sexual practices, lack of availability of a vaccine and the chronicity of the disease requiring lifelong treatment.(2) The disease r...Read More
Viral uveitis has myriad presentations. They may present as anterior uveitis, intermediate uveitis, acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN) and neuroretinitis. The causative viruses mainly include herpes group of viruses and human immunodeficiency virus (HIV). Other DNA viruses which cause uveitis are poxviruses, adenoviruses especially those that produce epidemic k...Read More
Eales Disease: Current Concepts in Etiopathogenesis and Management
Introduction Eales’ disease is an idiopathic retinal periphlebitis that primarily affects the peripheral retina in young adults. Eales’ disease was first described by Henry Eales, a British ophthalmologist, in 1880 and 1882.1,2 He found it in seven young, male patients ranging in age from 14 to 29 years with recurrent vitreous hemorrhage. In addition, these patients had history of headache, variat...Read More
Malarial Retinopathy: A Diagnostic Clue
Introduction Malaria is the most important of parasitic diseases of humans and remains today, as it has been for centuries a large burden on tropical communities. Cerebral malaria is the most important complication of falciparum malaria and also the leading cause of death in malaria 1. It is defined as an acute, symmetric encephalopathy associated with sequestration of parasite-infected erythrocyt...Read More