Anatomy of Vitreous

Dr. Parthopratim Dutta Majumder
Published Online: April 5th, 2020 | Read Time: 6 minutes, 2 seconds

Vitreous is a transparent, colour less gel like structure which occupies the posterior compartment of the eye. It comprises about 80% of the total volume of the globe (two third of total volume of eye), about 4mL. The surfaces of the intraocular structures that interface with vitreous are mainly basement membrane in nature e.g. pars plana of cilliary body, internal limiting membrane of retina and vitreous is attached to them with varying strength of adhesion.

Vitreous at a glance:

  • Contains more than 98% of water
  • It has viscosity more than 2-3 times than that of water.
  • Refractive index 1.33


The word “vitreous” is derived from a Latin word “vitrum” which means glass.

Attachments of vitreous:

Vitreous is attacvitreousattachmentshed to its surrounding structures by condensation of collagen fibrils. From strongest to weakest, these are-

  • Vitreous base-strongest
  • Posterior lens capsule with the help of hyaloideocapsular ligament of Weiger
  • Margins of the optic disc
  • At the macula
  • Along the retinal vessels –Most variable and weakest

Vitreous base
The vitreous base is the place of strongest adhesion of vitreous. Vitreous base forms a band of 4 to 6 mm width (1 to 2 mm anterior to the ora serrata and 1 to 3 mm posterior to it) which lies in the posterior aspect of the parsplana and adjacent anterior aspect of the ora serrata. There is strong adhesion between vitreous fibers of the vitreous base region and basement membrane of the nonpigmented epithelium of the cilliary body and internal limiting membrane of the periphery of the retina.

vitreous baseHyaloideocapsular ligament
Hyaloideocapsular ligament of Weiger or Retrolental ligament is another strong adhesion of vitreous and posterior capsule of lens. It is a circular adhesion, 8-9 mm in diameter .The circular line of adhesion between vitreous and posterior lens capsule is often termed as “Egger’s Line”. The strength of this retrolental adhesion and peripapillary adhesion of vitreous decreases with age. Within this circle, there lies a potential space of nonadhesion between vitreous and lens, known as space of Burger or Erggelet's space. (Also readAnatomy of Lens)

Vitreous is attached with the macula in an annular fashion with a diameter of 3 -4 mm.It is also attached alongside the larger retinal vessels.

vitroeus and lens interfaceFor description purpose, vitreous can be divided into a outer zone and central zone.

Outer zone of vitreous:
The outermost zone of vitreous is also known as the cortex. Most of the vitreous collagens are located in cortex and these collagen fibrils run parallel & perpendicular to retinal surface.

The shape of the vitreous is just like a sphere with an anterior depression which is known as patellar fossa or lenticular fossa or hyaloid fossa which supports the lens. Anterior surface of the vitreous is known as anterior hyaloid face which clinically behaves like a membrane.

Central zone:
The central zone has little collagen compared to outer vitreous and physically more liquid than the outer zone of vitreous. In this region, vitreous cells (hyalocytes) are less in number and collagen fibrils are thinly scattered.

Cloquets Canal:
The central vitreous is traversed by a canal which is known as cloquet or hyaloid canal or retrolental tract. It extends from the posterior surface of the lens to the optic nerve head. Basically it represents the remnants lumen of the course of hyaloid artery during embryogenesis. This space is devoid of collagen fibrils. It is 1 to 2 mm in diameter and “S” shaped from anterior to posterior.

Historical perspective:

Cloquet canal is named after French anatomist Jules Germain Cloquet (1790-1883)

vitreous anatomy

It starts from patellar fossa as a widening and after taking an “S” shaped course in central vitreous, again widens near the optic nerve head to form space of Martegiani. A remnant of incomplete atrophy of the hyaloid artery may be seen in this location and is called Bergmeister's papilla.

With age, the firm attachment of vitreous with optic nerve head loosens. When vitreous detaches completely, this peripapillary attachment becomes visible clinically as a partial or complete annular ring, which is known as Vogt or Weiss ring.

Hyalocytes or Vitreous Cells:

Though vitreous is an acellular structure, hyalocytes or vitreous cells are found in cortex adjacent to retina and cilliary body. They are found near the vitreous base, over the optic nerve head and in close proximity to the retinal vessels. Hyalocytes are basically mononuclear phagocytes or macrophages. Few fibrocytes and glial cells are also seen in vitreous.

Dr. Parthopratim Dutta Majumder
Sankara Nethralaya, Chennai
Illustrated Ocular Anatomy is a web based free-access portal for anatomy of eye. Perhaps it is the first of its kind as both the images and texts are authored by an ophthalmologist. Dr. Parthopratim Dutta Majumder completed his graduation and post-graduation from Silchar Medical College & Hospital, Assam University. He completed his fellowship in medical retina and uvea from Sankara Nethralaya and is now working in the department of uvea and intraocular inflammation as Consultant. He has written many chapters in many books. He was awarded with Dr. TLK Row Endowment Award for the best associate consultant 2010-11. He is life-memebr of the All India, Delhi, All Assam Ophthalmological Societies and uveitis society of India. He has received Nataraj Pillai award for best scientific paper in 2009. He has attended and presented paper in various national and international conferences. His areas of interest include medical management of uveitis and scleritis, phacoemulsification in uveitic cataracts and offcourse graphic design. For water mark free images please write to me at
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