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#Vitreoretina

79 articles
  1. Articles 10 Jan 2025 6 min read

    Do's and Don'ts of Managing a Nucleus Drop: A Guide for Beginners

    Managing a nucleus drop during cataract surgery is one of the most challenging and critical situations an ophthalmic surgeon may encounter. While it’s a rare occurrence, its management demands quick thinking, precise action, and a thorough understanding of both anterior and posterior segment techniques. The goals are always to preserve vision, prevent complications, and optimize the long-term outcomes for the patient. Different surveys in India have found the incidence rate of nucleus drop between 0.04-0.1%. (1,2) Dropped nucleus and cortical remnants occur most commonly in phacoemulsification, than other techniques of cataract surgery. (3) Certain conditions associated with posterior capsular or zonular weakness have a higher risk of nucleus drop in cataract surgery. These include the following (4): Pseudoexfoliation syndrome Advanced or intumescent cataract Traumatic cataract Previous intraocular surgeries like vitrectomy or glaucoma procedures Difficult situations like shallow AC, s

    Dr. Dhanashree Ratra · Dr. Sakshi Ramnani
  2. Articles 21 May 2023 9 min read

    Seven Important OCT Signs in CNVM

    1. Type of macular neovascularisation (MNV): Macular neovascularisation (MNV) is a broad disease entity characterised by the development of the abnormal vessels arising either from the retinal vasculature (deep capillary plexus) or choroidal vasculature (choriocapillaris). Choroidal neovascular membrane (CNVM) is a subtype of MNV, characterised by the abnormal growths of blood vessels from the choroidal capillaries that penetrate the retina, specifically into the sub-RPE and subretinal spaces. These vessels are extremely immature and extremely fragile, so they bleed and leak, de-structuring the macula, causing severe visual impairment. The classification of MNV is depicted below in Figure 1: Figure 1: A simple classification of macular neovascularisation (MNV): 2. Cause of CNVM: A CNVM is primarily classified based on the etiology into two categories: A) Age-related Macular Degeneration (AMD) associated CNVM and B) Non-AMD associated CNVMs. Causes of non-AMD associated CNVMs: Central s

    Dr. Ramesh Venkatesh · FVRF (Sankara Nethralaya) · +2 others
  3. Articles 13 Feb 2023 11 min read

    Optical Coherence Tomography Biomarkers in Diabetic Macular Edema

    One of the major microvascular complications of diabetes mellitus is diabetic retinopathy. Diabetic macular edema (DME) and proliferative diabetic retinopathy are the most common causes of vision loss in diabetic retinopathy. Pathogenesis of DME: A simplified understanding of the pathogenesis of DME formation is depicted in Figure 1: The role of vascular endothelial growth factor (VEGF) and inflammation in the pathogenesis of DME is depicted in Figure 2: OCT is a non-invasive imaging technique that is widely used in routine retina practice to obtain a high-definition cross section of all retinal layers and to measure their thickness. Recent advances in OCT imaging, such as the introduction of spectral-domain and swept source-based optical coherence tomography (OCT) and enhanced depth imaging, have enabled clinicians to detect and understand the various aspects of DME formation and treatment. This article will discuss the role of various OCT imaging biomarkers in identifying diabetic ma

    Dr. Ramesh Venkatesh · Aishwarya Joshi · +1 other
  4. Articles 25 Oct 2021 8 min read

    Anti-VEGFs made Easy for the Postgraduates

    The retina is a highly metabolic tissue and needs a constant high supply of oxygen. Insult to either choroidal or retinal vasculature can lead to a hypoxic state. Throughout the years, neovascularization has been seen to occur in areas neighboring such hypoxic areas. In 1989, this hypoxia-inducible and diffusible factor was discovered to be Vascular Endothelial Growth Factor (VEGF), initially coined as Vascular Permeability Factor (VPF). VEGF was found to be answerable for many types of retinopathies and the increased vascular permeability seen in them. VEGF is a heparin-binding dimeric glycoprotein with di-sulfide-linked A and B subunits. VEGF has been found to be produced by many cell types in the retina including vascular endothelial cells, retinal pigment epithelium, pericytes, Muller cells, retinal neurons, and astrocytes. It is necessary for the survival of retinal cells; prenatally for proper embryological development of the retina as well as postnatally for preserving adult mic

    Dr. Gunjan Prasai · Dr. Anadi Khatri · +1 other
  5. Articles 23 Sep 2021 13 min read

    Ten Pearls for Treating A Case of Retinopathy of Prematurity

    Introduction Retinopathy of Prematurity (ROP) is a potentially blinding retinal vasoproliferative disorder affecting premature and low birth weight infants. With improving survival of preterm infants with lower birth weights and gestational ages, ROP is reaching epidemic proportions in many middle- income countries.1 Although a majority of infants would develop a mild self-limiting disease, some can progress to tractional retinal detachment and become permanently and irreversibly blind. Timely detection and treatment along with good supportive neonatal care offer the best chance of successful outcomes in these infants. Key pearls of ROP management are described as under: Pearl 1: Which infants should be examined for ROP? The guidelines for screening infants for ROP vary between different countries and geographical regions based on individual incidence rates. For India, the current guidelines recommend that all infants with a birth weight of 2000 grams or less and /or gestational age le

    Prof. Mangat Ram Dogra · Dr. Deeksha Katoch
  6. Articles 13 Sep 2021 30 min read

    Central Retinal Vein Occlusion: A Comprehensive Review

    Introduction: The clinical entity of Central Retinal Vein Occlusion (CRVO) has been known since 1878 (1), and it is a common visually disabling disorder that may cause significant ocular morbidity. It commonly affects men and women equally and occurs predominantly in persons over the age of 65 years (2-4). Associated systemic vascular disease, including hypertension and diabetes, are present in these population groups. The prevalence rates range from 0.1% to 0.5% in the older adult population. (3-5) Younger individuals may have an underlying hypercoagulable or inflammatory Etiology (6,7) CRVO is the second most common retinal vascular disorder after diabetic retinopathy and is considered to be an important cause of visual loss. (8) The annual risk of developing any type of retinal vascular occlusion in the fellow eye is approximately 1% per year, and it is estimated that up to 7% of persons with CRVO may develop CRVO in the fellow eye within 5 years of onset in the first eye (9-11). CR

    Dr. Priyanka Gupta · Dr. Sandeep Kumar · +1 other
  7. Articles 10 Sep 2021 10 min read

    Ten Clinical Signs A Postgraduate Must Look For While Examining the Fundus

    1. Red Dots! : Microaneurysms Seen in Diabetic Retinopathy, retinal vein occlusions, hypertensive retinopathy, radiation retinopathy. Microaneurysms are usually the first ophthalmoscopically detectable sign of diabetic retinopathy. They are focal saccular outpouchings of the capillary wall due to pericyte loss. Arise from the deep part of the inner retinal capillary plexus, and are present in the inner nuclear layer.1 Features: Appear as small round red dots - usually seen at the posterior pole, especially temporal to the fovea. 10- 100 microns in diameter. Only > 30 microns is visible ophthalmoscopically (better on red-free illumination). < 30 microns can be seen on FFA and hence more microaneurysms are seen on FFA than fundus examination. Shapes – saccular, fusiform, pedunculated, focal bulge, irregular, mixed. FFA- Hyperfluorescent with leakage. OCT – Ring sign, span more than 1 retinal layer. Course- disappear in 3-6 months. Can continue to exudate, bleed or thrombose. 2. And it wa

    Dr. Sashwanthi Mohan · Dr. Snehal Bavaskar
  8. Articles 4 Sep 2021 6 min read

    Ten Points One Must Know on Toxic Anterior Segment Syndrome (TASS)

    TASS is an uncommon, non-infectious condition causing severe inflammation of the anterior segment structures without vitreous involvement [1],[2],[5]. The name TASS was coined by Monson and colleagues in 1992 [1],[3]. It is usually associated with phacoemulsification surgery but can also happen after procedures like penetrating keratoplasty, descemet stripping automated endothelial keratoplasty, deep anterior lamellar keratoplasty, vitrectomy and anterior and posterior segment phakic intraocular lenses. The alternative names of TASS include sterile post -operative endophthalmitis, toxic lens syndrome, toxic endothelial cell destruction syndrome and localized endophthalmitis [1],[3],[7]. 1. What is TASS? It is an acute sterile post-operative inflammatory condition affecting the anterior segment structures following intraocular surgery. It is usually seen within 12-48 hours of surgery and is due to the reaction of anterior segment structures to some toxic substance usually associated wit

    Dr. Priya Rasipuram Chandrasekaran
  9. Articles 26 Aug 2021 6 min read

    How to Quickly Read a Macular OCT Scan?

    Optical Coherence Tomography (OCT) is a quick, non-invasive, reproducible, and optical analog of ultrasound imaging which is as good as in vivo viewing of individual retinal layers histologically. In today’s practice, OCT is indisputably an essential diagnostic tool for every retinal surgeon. And so correct interpretation of OCT scans helps us in understanding the disease pathologically which in turn aids in prognosticating and making treatment decisions. How to quickly read a macular OCT? An OCT image gives you layer by layer information of retinal tissue. So if we segment the OCT image into 5 layer-wise sub-segments, it becomes very easy to read and interpret the retinal pathology. And also just by looking at the diseased/damaged retinal layer, we can identify probable clinical disease. These 5 OCT sub-segments can be used for quick interpretation of macular OCT scans. 1: VR (Vitreo-Retinal) Interface 2: Inner Retina 3: Outer retina 4: RPE/ BRUCHS MEMBRANE 5: Choroid Let us first rev

    Dr. Deepak Bhojwani
  10. Students Gallery 24 Aug 2021 2 min read

    i-File: Systemic Hypertension

    A 60-year male presented with C/O diminution of vision in the Right Eye. The patient is not a known case of any known systemic illness, although gives a vague c/o chest pain and the occasional headache. Examination revealed a vision of 4/60 with an IOP of 16mmHg as measured by GAT. The right Eye reveals the unremarkable anterior segment with minimal lenticular changes. Vitreous cavity quiet with fundus as shown. The left eye reveals a normal anterior and posterior segment. Question What are the positive findings as depicted in the fundus photo.? What are the investigations you would ask for? How will you manage this case? Answer Ocular 1) FUNDUS FLUORESCEIN ANGIOGRAM: disruption of retinal layers. These in turn will again help in educating the patient in terms of visual gain he is expected to gain In this case if one had to choose between FFA and OCT, FFA would be a better option. Management Managing this case is again in collaboration with a physician/ cardiologist Ocular 1) After con

    Dr. Bikramjit Pal

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