Uvea & Inflammatory Diseases

21–24 of 24 articles Page 3 of 3
All Cornea 36 Cataract 17 Glaucoma 14 Retina & Vitreous 72 Neurophthalmology 8 Oculoplasty 15 Uvea & Inflammatory Diseases 24 Miscellaneous 20 Oncology 9 Pediatric Ophthalmology 16
  1. 2 min read

    Ten Pearls for Treatment of TB Uveitis

    1. In TB-endemic countries, think of TB as a probable/possible etiology of uveitis in Presence of one or a few large full-thickness choroidal granulomas that show enhanced vascularity/RAP on FFA Retinal periphlebitis with subvascular retinitis/choroiditis lesions/scars that show extensive peripheral retinal ischemia. Multifocal serpiginoid choroiditis/Serpiginous-like choroiditis lesions with vitreous cells. 2. In the presence of any of the above clinical phenotypes, collect evidence of MTB infection by way of tuberculin skin test/QuantiFERON-TB Gold; X-ray/CT chest. The 2-step testing (Bayesian probability) improves the likelihood of MTB as a probable/possible etiology of uveitis in TB-endemic regions. 3. Polymerase chain reaction to detect MTB DNA from ocular fluids has low sensitivity limiting its utility in clinical practice. If positive, it confirms the diagnosis of TBU but a negative test does not rule out MTB. 4. Start 4-drug anti-TB drug regimen in consultation with an internis

    Prof. Amod Gupta
  2. 15 min read

    Acute Retinal Necrosis

    Acute retinal necrosis was first described in Japan by Urayama and colleagues who described six otherwise healthy patients, presented with panuveitis and retinal arteritis developing retinal detachment. At that point of time, this entity was known in the Japanese literature as “Kirisawa uveitis”1.Young and Bird first used the term “bilateral acute retinal necrosis” in 1978 2. In 1982 Culbertson and associates 3 first reported the possible involvement of a herpes group virus as the causative agent of acute retinal necrosis syndrome after histopathology and electron microscopy evaluation of an enucleated eye. The Executive Committee of the American Uveitis Society 4 de?ned the disease by its clinical characteristics and disease course in 1994. Epidemiology: Acute retinal necrosis generally affects healthy, immunocompetent individuals regardless of sex or race. However, Fisher et al found little male preponderance in their study 5. The disease affects typically young adults. Bimodal age d

    Dr. Parthopratim Dutta Majumder
  3. 15 min read

    Serpiginous Choroiditis: An Update

    The word “serpiginous” is an adjective which means “with a wavy or indented margin”. The serpiginous choroiditis shows the similar wavy or amoeboid like lesions in choroid as a result of inflammation of unknown aetiology. The serpiginous choroiditis may be defined as a chronic, progressive, usually bilateral, recurrent in?ammatory condition which affects the choroid, choriocapillaries and retinal pigment epithelium. This clinical entity was first reported by Junius in 1932 who termed it as “peripapillary retinochoroiditis”. Thereafter this clinical entity has passed through various nomenclatures by various authors (Table 1). The term “serpiginous choroidopathy” was coined by Gass in 1987. Table 1: Different nomenclatures of Serpiginous choroiditis by various authors Peripapillary choroidalsclerosis by Sorsby, 1939 Helicoid peripapillary chorioretinal degeneration by Franceschetti, 1962 Geographic helicoids peripapillary choroidopathy by Schatz,1974 Geographic choroiditis by Baarsma,197

    Dr. Parthopratim Dutta Majumder
  4. 13 min read

    Retinal Vasculitis

    Retinal vasculitis is an inflammatory disease of the blood vessels of the retina that may be associated with primary ocular conditions or with inflammatory or infectious diseases in other parts of the body (systemic diseases). It has been defined as the vascular leakage and staining of vessel walls on fluorescein angiography, with or without the clinical appearance of fluffy, white perivascular infiltrates in an eye with evidence of inflammatory cells in the vitreous body or aqueous humor 1. Typically, retinal vasculitis is divided into entities localized to the retina and into systemic diseases involving the eye. These include certain ocular disorders, systemic autoimmune disorders, and some infectious diseases. Etiology: The common primary causes of retinal vasculitis where vessel is the primary target of the inflammatory process are: (a) Localized to the eye - Idiopathic - Intermediate uveitis of the pars planitis type - Frosted branch angiitis - Idiopathic retinal vasculitis, aneur

    Dr. Reema Bansal · Prof. Amod Gupta