Intraocular Lymphoma: Ten Points Every Ophthalmologist Should Know
1. Epidemiology of Intraocular Lymphoma: Intraocular Lymphoma is a rare malignancy accounting for 0.01% of ophthalmic conditions. The term includes primary intraocular lymphoma (PIOL) with or without primary central nervous system lymphoma (PCNSL). 1 Majority of the patients with lymphoma are over 50 years of age. 2 2. Presentations and Potential for Misdiagnosis of Intraocular Lymphoma: PIOL has varied presentations; but most commonly, it masquerades as intermediate and/or posterior uveitis; seen mostly as subretinal yellowish creamy lesions with an associated leopard skin type of retinal hyperpigmentation (Figure 1). 3 Figure 1: Shows typical subretinal yellowish creamy lesions with an associated leopard skin type of retinal hyperpigmentation seen in a 44-year-old lady with biopsy proven CNS lymphoma It usually originates from vitreoretina, thus known as primary vitreoretinal lymphoma (PVRL) or from uveal tissue and also the optic nerve. 4 In our experience it has masqueraded and bee

