Embryology of Eye
Introduction The eyeball development begins early in the 4th week of intrauterine life with formation of optic vesicle (a diverticulum) from diencephalon. The structure of eyeball is shown in Figure 1. Various components of eyeball are derived from the following sources: Retina, iris and optic nerves are derived from optic vesicle that arises from neuroectoderm of diencephalon. Lens and corneal epithelium are derived from lens placode that arises from surface ectoderm. Fibrous and vascular coats of eyeball are derived from mesodermal condensation surrounding the optic vesicle. Choroid and sclera are derived from migrating neural crest cells. Figure 1: Fully developed eyeball Optic Vesicle and Lens Vesicle Formation of optic sulcus: On 22nd day, wall of the diencephalon shows thickening and depression to form optic sulcus. Formation of the optic sulcus or groove is the first indication for development of the eye (Figure 2A). Formation of optic vesicle: Optic sulcus further invaginates l

