Ten Tenets of Diagnostic Vitrectomy
Diagnosis of posterior segment inflammatory or infectious disease is mostly based on clinical presentation, ocular imaging and specific laboratory tests. However, in the absence of a characteristic clinical picture of a specific disease the diagnosis of uveitis can be challenging. It has been reported that upto 33% of uveitis remain undiagnosed. Moreover, some of the malignant or infective diseases of the eye may mimic an inflammatory pathology leading to delay in diagnosis and subsequently poor outcomes. Intraocular biopsy may be helpful in clinching the diagnosis in these situations. With the improvement in laboratory testing and vitrectomy instrumentations, diagnostic vitrectomy is increasingly being performed in clinical practice. 1. Indications 1,2 Diagnostic dilemma Patient fails to respond to standard systemic anti-inflammatory therapy Atypical clinical presentations Inconclusive non-invasive laboratory work-up Significant vitreous inflammation concerning for malignancy, infecti

