HLA-B27 associated Acute Anterior Uveitis
Introduction Acute anterior uveitis (AAU) results from a breakdown of the blood-aqueous barrier and acute inflammation of the iris and ciliary body. It is the most common form of uveitis encountered the world over. Keratic precipitates (KPs) are characteristic of AAU and represent inflammatory cells that deposit on the corneal endothelium due to the upregulation of adhesion molecules in response to local chemoattractant cytokines. The association between HLA (human leukocyte antigen)-B27, a human major histocompatibility complex (MHC), and its gamut of inflammatory diseases and HLA-B27 associated AAU was first described in 1973 and to date, it remains one of the strongest HLA-disease associations known. Epidemiology Though most epidemiological studies are based in tertiary referral centers and have a referral bias towards posterior and intermediate uveitis, anterior uveitis is the most common form of uveitis encountered in most parts of the world. HLA-B27 AAU comprises cases of acute a

